Autism Studies

“Immunoexcitotoxicity as the central mechanism of etiopathology and treatment of autism spectrum disorders: A possible role of fluoride and aluminum” Anna Strunecka, Russell L. Blaylock, Jiri Patocka, and Otakar Strunecky. 2018

“We demonstrate that fluoride and aluminum (Al3+) can exacerbate the pathological problems by worsening excitotoxicity and inflammation. While Al3+ appears among the key suspicious factors of ASD, fluoride is rarely recognized as a causative culprit. A long-term burden of these ubiquitous toxins has several health effects with a striking resemblance to the symptoms of ASD.”

Maternal breastfeeding and autism spectrum disorder in children: A systematic review and meta-analysis. Tseng PT 2017

This meta-analysis provides evidence that breastfeeding (exclusively or including additional supplements) may protect against ASD. Prospective longitudinal research is required to disentangle the complex relationships and to explore potential pathophysiological mechanisms.

“Vaccines are not associated with autism: An evidence-based meta-analysis of case-control and cohort studies” Luke E. Taylor, Amy L. Swerdfeger, Guy D. Eslick. 2014

“Studies were included that looked at either MMR vaccination, cumulative mercury (Hg) or cumulative thimerosal dosage from vaccinations to ensure all proposed causes of ASD or regression were investigated.”

[Editor’s note: Please take special note that only MMR vaccine, and or cumulative mercury exposure, was investigated before coming to the conclusion that ALL VACCINES are not associated with Autism. Please see further articles here.]

“Transcriptomic analyses of neurotoxic effects in mouse brain after intermittent neonatal administration of thimerosal.” Li X,Qu F,Xie W, et al. 2014

“Thimerosal-treated mice exhibited neural development delay, social interaction deficiency, and inclination of depression.”

“Methodological Issues and Evidence of Malfeasance in Research Purporting to Show Thimerosal in Vaccines Is Safe”. Brian Hooker, et al. 2014

 

“Maternal immune activation causes age and region-specific changes in brain cytokines in offspring throughout development.” Garay, Paula A. Hsiao, Elaine Y. Patterson, Paul H. McAllister, A K. Brain, behavior, and immunity 2013; 31():54-68 PubMed Link 

“Together, these data indicate that MIA leads to long-lasting, region-specific changes in brain cytokines in offspring—similar to those reported for ASD and SZ—that may alter CNS development and behavior.”

“A positive association found between autism prevalence and childhood vaccination uptake across the U.S. population”. Delong G. 2011

“A positive and statistically significant relationship was found: The higher the proportion of children receiving recommended vaccinations, the higher was the prevalence of AUT or SLI. A 1% increase in vaccination was associated with an additional 680 children having AUT or SLI.”

Hepatitis B vaccination of male neonates and autism diagnosis, NHIS 1997-2002″. Gallagher CM, Goodman MS. 2010

“Findings suggest that U.S. male neonates vaccinated with the hepatitis B vaccine prior to 1999 (from vaccination record) had a threefold higher risk for parental report of autism diagnosis compared to boys not vaccinated as neonates during that same time period.”

“Immune-glutamatergic dysfunction as a central mechanism of the autism spectrum disorders”. Blaylock RL, Strunecka A. 2009

“We suggest that environmental and dietary excitotoxins, mercury, fluoride, and aluminum can exacerbate the pathological and clinical problems by worsening excitotoxicity and by microglial priming.”

“Acetaminophen (paracetamol) use, measles-mumps-rubella vaccination, and autistic disorder: the results of a parent survey.” Schultz ST, et al. 2008

“Acetaminophen use after measles-mumps-rubella vaccination was significantly associated with autistic disorder when considering children 5 years of age or less (OR 6.11, 95% CI 1.42-26.3), after limiting cases to children with regression in development (OR 3.97, 95% CI 1.11-14.3), and when considering only children who had post-vaccination sequelae (OR 8.23, 95% CI 1.56-43.3), adjusting for age, gender, mother’s ethnicity, and the presence of illness concurrent with measles-mumps-rubella vaccination.”

“Maternal Immune Activation Alters Fetal Brain Development through Interleukin-6”. Stephen E. P. Smith, Jennifer Li, Krassimira Garbett, Karoly Mirnics, and Paul H. Patterson. 2007

A prospective study of thimerosal-containing Rho(D)-immune globulin administration as a risk factor for autistic disorders. Geier DA, Geier MR. 2007

“Children with ASDs (28.30%) were significantly more likely (odds ratio 2.35, 95% confidence interval 1.17-4.52, p < 0.01) to have Rh-negative mothers than controls (14.36%). Each ASD patient’s mother was determined to have been administered a TCR during her pregnancy.”

Environmental mercury release, special education rates, and autism disorder: an ecological study of Texas, Raymond F. Palmera, 2006

On average, for each 1000 lb of environmentally released mercury, there was a 43% increase in the rate of special education services and a 61% increase in the rate of autism. The association between environmentally released mercury and special education rates were fully mediated by increased autism rates. This ecological study suggests the need for further research regarding the association between environmentally released mercury and developmental disorders such as autism. These results have implications for policy planning and cost analysis.

 

Breastfeeding, infant formula supplementation, and Autistic Disorder: the results of a parent survey. Stephen T Schultz 2006

The results of this preliminary study indicate that children who were not breastfed or were fed infant formula without docosahexaenoic acid/arachidonic acid supplementation were significantly more likely to have autistic disorder.

“Immunological findings in autism”. Cohly HH, Panja A. 2005

“Elevated levels of measles antibodies in children with autism”. Singh VK, Jensen RL. 2003

“Abnormal measles-mumps-rubella antibodies and CNS autoimmunity in children with autism”. Singh VK, et al. 2002

SIDS Studies

“DPT immunization and SIDS”. Kalyani Srinivas, G. Preeti, Sujatha Pasula. 2015

“It is found that mortality with SIDS in the period zero to three days following DTP to be 6.9 times that in the period beginning 30 days after immunization (95 per cent confidence interval, 1.4 to 28)”

“Re-analyses of case-control studies examining the temporal association between sudden infant death syndrome and vaccination”. Ronny Kuhnert, et al. 2012 PDF here Reanalysis of case-control studies examining

“There is no increased or reduced risk of sudden infant death during the period after the vaccination. The previously reported protective effect seen in case control studies is based on the inclusion of unvaccinated cases.”

[Editor’s Note: This study erases any protective effect of vaccines regarding SIDS, because it only came to that conclusion by including a large majority of unvaccinated SIDS cases who died before reaching 2 months old, and thus died before they were eligible for vaccines. A vaccine cannot prevent a death that occurs before a vaccine would be routinely given. However, of infants who lived past 2 months old, they were 4 times more likely to be vaccinated prior to their death. Further research is needed to full understand the mechanism of SIDS, misdiagnosis, and the contributions of vaccines. Explore SIDS here.]

“Diphtheria-Tetanus-Pertussis Immunization and Sudden Infant Death Syndrome”.  ALEXANDER M. WALKER, MD, DRPH, HERSHEL JICK, MD, DAVID R. PERERA, MD, MPH, ROBERT S. THOMPSON, MD, AND THOMAS A. KNAUSS, MD, PHD. 1987

“Focusing on very narrow time intervals following immunization, we found the SIDS mortality rate in the period zero to three days following DTP to be 7.3 times that in the period beginning 30 days after immunization (95 per cent confidence interval, 1.7 to 31).”

“Sudden twin infant death on the same day: a case report and review of the literature” Huang, et. al. 2013 e.Huang et Twins

[Editors note: Ten week old twin infants received the first doses of oral polio and diphtheria, pertussis, and tetanus (DPT) vaccines 60 days after birth. So day 60 they were vaccinated and they died at 10 weeks, or day 70. Ten days after vaccination, these twins died simultaneously on the same night.]

Aluminum Adjuvant Studies

“Aluminium in brain tissue in autism”. Mold M, Umar D, King A, Exley C. 2018

“The pre-eminence of intracellular aluminium associated with non-neuronal cells was a standout observation in autism brain tissue and may offer clues as to both the origin of the brain aluminium as well as a putative role in autism spectrum disorder.”

 

Synergism in aluminum and mercury neurotoxicity. Peter N Alexandrov, Aileen I Pogue. 2018

“This is the first report on the neurotoxic effects of aluminum sulfate and/or mercury sulfate on the initiation of inflammatory signaling in human brain cells in primary culture. The effects aluminum+mercury together on other neurologically important signaling molecules or the effects of other combinations of common environmental metallic neurotoxins to human neurobiology currently remain not well understood but certainly warrant additional investigation and further study in laboratory animals, in human primary tissue cultures of CNS cells, and in other neurobiologically realistic experimental test systems.”

 

“The putative role of environmental aluminium in the development of chronic neuropathology in adults and children. How strong is the evidence and what could be the mechanisms involved?”. Gerwyn Morris, Basant K. Puri, and Richard E. Frye. 2017

“Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations”. Tomljenovic L, Shaw CA. 2012

“Autoimmunity following hepatitis B vaccine as part of the spectrum of ‘Autoimmune (Auto-inflammatory) Syndrome induced by Adjuvants’ (ASIA): analysis of 93 cases”Zafrir Y, Agmon-Levin N, Paz Z, Shilton T, Shoenfeld Y. 2012

Aluminum Adjuvant Linked to Gulf War Illness Induces Motor Neuron Death in Mice, Michael S. Petrik. 2007.

The findings suggest a possible role for the aluminum adjuvant in some neurological features associated with GWI and possibly an additional role for the combination of adjuvants.

Allergy / Adverse Event Studies

Childhood vaccine status and correlation with common nonvaccine‐preventable illnesses, Michelle M. Anderson DNP, FNP, 2017.

“Fully immunized group had significantly more ear infections than partial or unimmunized. The unimmunized group had significantly more colds and flu.”

Pilot comparative study on the health of vaccinated and unvaccinated 6- to 12-year-old U.S. children, Anthony Mawson, 2017

“The vaccinated were less likely than the unvaccinated to have been diagnosed with chickenpox and pertussis, but more likely to have been diagnosed with pneumonia, otitis media, allergies and NDD. After adjustment, vaccination, male gender, and preterm birth remained significantly associated with NDD. However, in a final adjusted model with interaction, vaccination but not preterm birth remained associated with NDD, while the interaction of preterm birth and vaccination was associated with a 6.6-fold increased odds of NDD (95% CI: 2.8, 15.5). In conclusion, vaccinated homeschool children were found to have a higher rate of allergies and NDD than unvaccinated homeschool children.”

Increased Risk of Noninfluenza Respiratory Virus Infections Associated With Receipt of Inactivated Influenza Vaccine.  Benjamin J. Cowling, et. al. 2012

“We randomized 115 children to trivalent inactivated influenza vaccine (TIV) or placebo. Over the following 9 months, TIV recipients had an increased risk of virologically-confirmed non-influenza infections (relative risk: 4.40; 95% confidence interval: 1.31-14.8). Being protected against influenza, TIV recipients may lack temporary non-specific immunity that protected against other respiratory viruses.”

Infant mortality rates regressed against number of vaccine doses routinely given: Is there a biochemical or synergistic toxicity? Neil Z Miller and Gary S Goldman. 2011

“Using the Tukey-Kramer test, statistically significant differences in mean IMRs were found between nations giving 12–14 vaccine doses and those giving 21–23, and 24–26 doses. A closer inspection of correlations between vaccine doses, biochemical or synergistic toxicity, and IMRs is essential.”

“The relationship between vaccine refusal and self-report of atopic disease in children”. Rachel Enriquez, PhD. 2005

“Parents who refuse vaccinations reported less asthma and allergies in their unvaccinated children.”

“Vaccination and Allergic Disease: A Birth Cohort Study” Tricia M. McKeever, PhD, 2004.

“Our univariate analysis showed that exposure to DPPT was associated with an increased risk of developing asthma (hazard ratio [HR] = 14.0; 95% confidence interval [CI] = 7.3, 26.9) and eczema (HR = 9.40; 95% CI = 5.92, 14.92)”

In this observational study analyzing computerized primary care records, we found an association between MMR and DPPT vaccination and the incidence of asthma and eczema, but these associations appeared to be limited to the minority of children who rarely seek care from a GP. This limited association is more likely to be the result of bias than a biological effect.”

[Editor’s Note: when an association is found between vaccination and allergy, it is considered bias, because they are so healthy, because they are unvaccinated, that they do not need to see a doctor.]

Symptoms after accelerated immunisation. Mary E B Ramsay,  1992.

[Editor’s note: Out of 107 infants, had reactions to vaccines that compelled the parents to not continue with the pertussis component of the vaccine:

“Only one of the children had a genuine contraindication to further doses of pertussis vaccine, when he developed a temperature of 40.5°C (104.9 degrees F) on evening 2 after vaccination (measured by the mother). The second child was afebrile but seemed distressed with a high pitched cry on the first evening. Although the crying was neither prolonged nor inconsolable and therefore did not constitute a contraindication to further pertussis vaccine, the mother opted to complete with diphtheria-tetanus only vaccine.”

[Editor’s note: We are told that vaccine reactions are “one in a million” and in this study of 107 infants, 2 reportedly had reactions that warranted caution, and exempted at least one of the infants from further vaccination.]

Confounding in Studies of Adverse Reactions to Vaccines, Paul Fine, 1992.

Most published studies have reported a deficit of sudden infant death syndrome among vaccinees, which may reflect confounding in their study designs. An expression is derived to explore the extent of underestimation that may be introduced in such studies, under different sets of conditions. Confounding of this sort is a general problem for studies of adverse reactions to prophylactic interventions, as they may be withheld from some individuals precisely because they are already at high risk of the adverse event.

Evidence Concerning Pertussis Vaccines and Central Nervous System Disorders, Including Infantile Spasms, Hypsarrhythmia, Aseptic Meningitis, and Encephalopathy, Institute of Medicine (US) Committee to Review the Adverse Consequences of Pertussis and Rubella Vaccines; Howson CP. 1991

The evidence is consistent with a causal relation between  and acute encephalopathy, defined in the controlled studies reviewed as encephalopathy, encephalitis, or encephalomyelitis. 

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